Tingling in your thumb, index or middle finger? It could be Carpal Tunnel Syndrome. Cause: Pressure on the median nerve in the wrist. Symptoms: Tingling Numbness Reduced grip strength My middle finger twitch a lot when I position the finger this way. Doesn't happen with other fingers The Surprising Reasons Behind Your Finger Twitching Your Health Magazine 5 Reasons Your Fingers Twitch How to Stop it for Good